Combined preparation. Paracetamol has antipyretic and analgesic effect: reduces pain, observed in cold conditions – a sore throat, headache, muscle and joint pain, reduces fever. Phenylephrine has a vasoconstrictor effect – reduces edema and hyperemia of the mucous membranes of the upper respiratory tract and sinuses.Chlorphenamine has anti-allergic effect: eliminates itchy eyes, nose, and throat, edema and hyperemia of the mucous membranes of the nasal cavity, nasopharynx equipoise steroid and sinuses, reduces exudative manifestations. Caffeine has a stimulating effect on the central nervous system, which reduces the fatigue and sleepiness to improve mental and physical performance.
Symptomatic treatment of “colds”, SARS, including influenza (a feverish syndrome, pain, rhinorrhea).
Severe atherosclerosis of the coronary arteries; hypertension (Severe); diabetes (Severe), hypersensitivity to paracetamol and other components of the drug; reception of other preparations containing substances that are part of the Rinzai; concomitant use of tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), beta-blockers;pregnancy, lactation; children’s age (15 years).
When hypertension, hyperthyroidism, equipoise steroid pheochromocytoma, diabetes, asthma, chronic obstructive pulmonary disease, deficiency of glucose-6-phosphate dehydrogenase, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), hepatic and / or renal failure, closure form of glaucoma, prostatic hyperplasia.
Dosing and Administration
Inside. Children older than 15 years and adults – 1 tablet 3 – 4 times a day. The maximum daily dose – 4 tablets. The course of treatment is not more than 5 days.
Allergic reactions (including skin rash, pruritus, urticaria, angioedema), dizziness, disturbance of sleep, irritability, dilated pupils; increased blood pressure, tachycardia; nausea, vomiting, epigastric pain; dry mouth; urinary retention; paresis of accommodation, increased intraocular pressure; anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia;hepatotoxicity, nephrotoxicity (renal colic, Glycosuria, interstitial nephritis, papillary necrosis); bronchial obstruction.
Tied usually paracetamol, appears after taking more than 10-15 g of the latter. There are: pale skin, anorexia, nausea, vomiting; gepatonekroz; increased activity of “liver” transaminases, increased prothrombin time. With symptoms of overdose seek emergency medical attention. Treatment: gastric lavage, followed by the appointment of activated carbon; symptomatic therapy, the introduction of methionine in 8-9 hours after the overdose and acetylcysteine – 12 hours.
Interaction with other drugs
It enhances the effects of equipoise steroid inhibitors of monoamine oxidase (MAO), sedatives, ethanol.
Antidepressants, antiparkinsonian agents, antipsychotics, phenothiazine derivatives – increase the risk of urinary retention, dry mouth, constipation. Glucocorticoids increase the risk of developing glaucoma.Paracetamol reduces the effectiveness of uricosuric drugs. Ethanol enhances the sedative effect of antihistamines drugs. Chlorphenamine simultaneously with inhibitors of monoamine oxidase (MAO), furazolidone can lead to a hypertensive crisis, excitation, hyperpyrexia. Tricyclic antidepressants increase the effect of phenylephrine adrenomimeticheskoe, co-administration of halothane increases the risk of ventricular arrhythmias. Decreases hypotensive effect of guanethidine, which, in turn, increases the activity of alpha-Adrenomimeticalkie phenylephrine.
When concomitant administration with Barbitura, phenytoin, carbamazepine, rifampicin and other inducers of microsomal liver enzymes increased risk of hepatotoxic action of paracetamol.
During the period of treatment should refrain from drinking alcohol, hypnotics and anxiolytics (tranquilizers) medications. Do not take with other medicines containing paracetamol.
Effects on ability to drive vehicles and drivers operating mechanisms
During the period of treatment equipoise steroid should refrain from driving cars and other activities potentially hazardous activities that require high concentration and psychomotor speed reactions. biomex labs