The absorption of the drug after ingestion of a relatively fast, and is approximately 1 hour. Average bioavailability – 0.63%, decreases in food intake. Relationship to plasma proteins – 24%. The volume of distribution – 6.3 l / kg. There is no evidence of risedronic acid metabolism system. Approximately half of the absorbed dose is excreted in the urine within 24 hours. The average renal clearance is 105 ml / min and mean total clearance is 122 ml / min. Renal clearance is independent of the concentration of the drug, there is a linear relationship between renal clearance and creatinine clearance. Unabsorbed equipoise for sale acid is excreted in the feces in unmodified form.
- Treatment of established postmenopausal osteoporosis.
- Hypersensitivity to the drug;
- Severe renal impairment (creatinine clearance less than 30 mL / min);
- Pregnancy and breast-feeding (lactation);
- Children under 18 years old.
The caution in patients with erosive and ulcerative lesions of the mucous membrane of the gastrointestinal tract (including history), in patients with impaired function of the esophagus in history (such as stricture or ahlaziya).
Dosage and administration
The recommended dose for adults: 35 mg once a week. The tablet should be taken in the same day of the week. Suction risedronic acid depends on the meal, so to ensure adequate absorption patients should take RIZENDROS ® at least 30 minutes before the first meal, other drug or drink (other than water).
Patients should be explained that if they miss a dose , you need to take medication in the day when they were talking about it. Then, the patient should return for equipoise for sale receiving one pill once a day during the normal reception. Do not take two tablets in the same day.
The tablet should be taken as a whole and do not chew, better standing and drink plain water (> 120 ml). After taking the pill, patients should not lie down for 30 minutes.
During treatment to the observance of adequate diet with sufficient calcium and vitamin D. If necessary, possible additional designation of calcium and vitamin D.
Side effect From the digestive system : often – indigestion, nausea, gastralgia, abdominal pain, constipation, diarrhea; sometimes – esophagitis, esophageal ulcers and stomach, gastritis, colitis, dysphagia, regurgitation, duodenitis, glossitis, esophageal stricture, violation of liver function. From the nervous system : headache, dizziness, asthenia, fatigue, leg cramps, myasthenia gravis. With side of the musculoskeletal system : skeletal muscle pain, leg cramps. From the senses : acute iritis (redness of the sclera, pain in the eyes), amblyopia, blurred vision, dry mucous membranes of the eyes, ringing in the ears. Allergic reactions : skin rash. Other : bone pain, arthralgia, bronchitis (cough), sinusitis, chest pain, peripheral edema, slight transient hypocalcemia and hypophosphatemia.
Overdose Symptoms of (potential) :. Hypocalcemia Treatment : milk reception, appointment of antacids containing magnesium, calcium or aluminum. With substantial overdose to remove unabsorbed drug is recommended to carry out gastric lavage.
Interaction with other medicaments
Medicaments containing polyvalent cations equipoise for sale such as calcium, magnesium, iron and aluminum, can reduce the absorption of the drug. No clinically significant interactions with non-steroidal anti-inflammatory drugs (in the including acetylsalicylic acid), blockers of H 2 histamine receptors, proton pump inhibitors, antacid drugs, blockers of slow calcium channels, beta-blockers, thiazide diuretics, corticosteroids, anticoagulants, anticonvulsants drugs means of cardiac glycosides.
Compatible with hormone replacement drugs.
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Before starting therapy with hypocalcemia must be corrected, as well as other pathologies, impacting on bone and mineral metabolism (eg parathyroid dysfunction, deficiency of vitamin D). If insufficient intake of dietary calcium and vitamin D supplementation with their needs.
The use of bisphosphonates is accompanied by a number of esophagitis, and ulcers of the esophagus. Therefore, patients must strictly comply with the dosing instructions (see. “Dosage and Administration” section).
Patients who are unable to stay for 30 minutes in a vertical position after taking the drug, as well as patients with impaired function of the esophagus in history (such as stricture or ahlaziya) risedronic acid should be used with extreme caution because of limited clinical experience with him in these patients.
The physician prescribes a equipoise for sale treatment, I am obliged to emphasize the importance of compliance with the dosage regimen instructions in these patients. anabolic steroids online pharmacy
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