Completeness beginning insulin absorption and the effect depends on the site of injection (abdomen, thigh, buttocks), the dose (amount of injected insulin), insulin concentration in the formulation, etc. distributed in the body unevenly.; It does not cross the equipoise dosage placental barrier and into breast milk. It destroyed insulinase mainly in the liver and kidneys. Excreted by the kidneys (30-80%).
- Type 1 diabetes.
- Saharnyy.diabet type 2 stage of resistance to oral hypoglycemic agents, partial resistance to these drugs (during combination therapy), intercurrent disease.
- Type 2 diabetes in pregnancy.Contraindications
- Increased individual’s sensitivity to insulin, or any of the components.
- Hypoglycemia.Pregnancy and lactation are no restrictions on treatment of diabetes with insulin during pregnancy, not, as insulin does not cross the placental barrier. When planning a pregnancy and during it is necessary to intensify the treatment of diabetes. The need for insulin usually decreases in the I trimester of pregnancy and is gradually increased side effects of equipoise in the II and III trimester. During birth and immediately after their need for insulin can dramatically decrease. Shortly after birth, insulin requirements equipoise dosage quickly returns to a level that was before pregnancy. Restrictions on treatment of diabetes with insulin during lactation is not. However, you may need to decrease the dose of insulin, therefore, should be closely monitored for several months to stabilize insulin requirements.Dosing and Administration The drug is intended for subcutaneous administration. Dose determined by the physician individually in each case based on the blood glucose concentration. On average, the daily dose ranges from 0.5 to 1 IU / kg body weight (depending on the individual patient and the concentration of blood glucose). Contraindicated intravenous . Low insulin must correspond to the room. The drug is usually administered subcutaneously equipoise dosage in the thigh. Injections can be done as well in the anterior abdominal wall, buttocks or shoulder area in the projection of the deltoid muscle. It is necessary to change the injection site within the anatomical region to prevent the development of lipodystrophy. When insulin administered subcutaneously care should be taken not to fall into a blood vessel at the injection. After injection, do not massage the injection site. Patients should be trained in the proper use of the device for administering insulin. Cartridges NPH before use should be rolled between your hands in a horizontal position and shake 10 times to resuspend the insulin to the state until it takes the form of a homogeneous turbid liquids or milk. Do not allow the appearance of the foam, which may interfere with the proper set of doses. Cartridges should be checked carefully. Do not use insulin if it is after, mixing the flakes are, if to the bottom or wall of the cartridge stuck solid white particles, giving it a kind of frozen. The device does not allow cartridges to mix their contents with other insulin directly into the cartridge. Cartridges are not designed to be refilled. When using cartridges should follow the manufacturer’s instructions with regard to filling the cartridge into the pen and the needle attachment. It is necessary to introduce the drug equipoise define in accordance with the manufacturer’s equipoise dosage pen. After the introduction you need to unscrew the needle using the outer needle cap, and immediately securely destroy it. Removing the needle immediately after injection ensures sterility prevents leakage of air from entering and possibly clogging the needle. Then, the cap should be put on the handle. The needles should not be reused. Located in the use of drugs stored at room temperature (15 to 25 ° C) no more than 28 days, protected from direct sunlight and heat.